List
S. Suman1, P. Karthikeyan2, S. Moulishankar3, S. Sridhar 4, G. Raaja5*, G.S. Aathithiah6,M. Vetriselvan7, Joemon8, R. Pachiyappan9, B. Devendran10

Authors:

1Managing Director, Vijayani Nutraceuticals Pvt Ltd, 2Director, Vijayani Nutraceuticals Pvt Ltd, 3Director, Vijayani Nutraceuticals Pvt Lt, 4Principal Research Investigator, Ashram Siddha Research Institute, 5Medical Officer, Vijayani Nutraceuticals Pvt Ltd, 6Medical Officer, Vijayani Nutraceuticals Pvt Ltd, 7General Manager, Vijayani Nutraceuticals Pvt Ltd, 8Manufacturing Incharge, Vijayani Nutraceuticals Pvt Ltd, 9Product Development, Oriens Global Marketing Pvt Ltd, 10Pharmacologist, Vijayani Nutraceuticals Pvt Ltd.

Corresponding Author:

*Dr. G. Raaja, Medical Officer, Vijayani Nutraceuticals Pvt. Ltd., Chennai, Tamil Nadu, India.

Email ID: raaja.ayurdoctor@gmail.com

Abstract

Introduction: Oxidative stress plays a significant role in the development of various health conditions, including anemia (Paanduroga), muscle wasting (Dhathukshaya), general weakness (Dourbalya), and nervous debility. Chronic exposure to environmental toxins, poor diet, stress, and lifestyle disorders contributes to increased free radical production, leading to cell damage, inflammation, and weakened immune function. Conventional treatments focus on synthetic antioxidants and dietary modifications, but these may not always be effective and could pose long-term side effects. Ayurvedic medicine offers a natural and holistic approach to combating oxidative stress, supporting tissue regeneration, and enhancing immunity. This study clinically validates Total Antioxidant Capsule, a proprietary Ayurvedic formulation, for its efficacy in improving antioxidant levels, reducing inflammation, and enhancing immune function. The primary objective of this Phase-II-A, single-center, open-label, therapeutic exploratory clinical trial was to evaluate the efficacy and safety of Total Antioxidant Capsule in relieving oxidative stress-induced conditions, improving energy levels, and enhancing immune function.

Methods: A total of 20 patients with oxidative stress-related symptoms were enrolled following ethical clearance. Patients were administered 1-2 capsules twice daily with lukewarm water for 30 days. Clinical investigations and laboratory assessments were conducted on Day 1 (Baseline) and Day 30 (End of Trial) by qualified AYUSH practitioners. Parameters such as fatigue, muscle strength, inflammation markers, hemoglobin levels, and immune response were monitored throughout the study.

Results: At the end of 30 days, 80% (16 patients) exhibited very good improvement, 15% (3 patients) showed moderate improvement, and 5% (1 patient) had mild improvement. The formulation significantly reduced inflammation, enhanced antioxidant levels, and improved overall vitality. No adverse effects were reported.

Conclusion: The study confirms that Total Antioxidant Capsule is an effective Ayurvedic intervention for reducing oxidative stress, improving energy levels, and strengthening immune function. The formulation demonstrated significant improvements in overall health and vitality, making it a promising natural alternative. Further large-scale trials are recommended for broader validation.

Keywords:   Oxidative stress, Anemia, Muscle wasting, Nervous debility
Received on 29th January 2025; Revised on 18th   February 2025; Accepted on 28th February 2025, DOI:10.36678/IJMAES.2025.V11I01.009

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